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The transcription of the IGF-1 (insulinlike growth factor 1) gene generates its 3 mRNA isoforms: IGF-1Ea, IGF-1Eb and IGF-1Ec (often called also as MGF or mechano growth factor). This means, IGF-1Ec is a splice variant of IGF-1, sharing an identical mature region, but with a different E domain. IGF-1Ec has been shown in vitro as well as in vivo to induce growth and hypertrophy in mechanically stimulated or damaged muscle. It is naturally occurring endogenous peptide, but it can be produced also synthetically. 

When mechanical overload is introduced to a muscle (as by weight training), the IGF-1 gene released and is differentially spliced during the bodies response. Initially, it is spliced to produce predominantly IGF-1Ec (called the MGF splice variant of IGF-1). This early splicing stimulates satellite cells into activation. Which in turn allows the activation of extra undamaged nuclei to grow new muscle fiber and tissue. In a rodent study, a single intramuscular injection into muscle resulted in a 25% increase in mean muscle fibre cross-section area within three weeks. Using a similar protocol, liver-derived IGF-1 took four months to produce a 15% increase. It would also appear that with regards to age, the young have a better ability to respond to MGF, and that the elderly experience a decreased response to MGF which results in a decreased ability to stimulate the growth of new muscle tissue.